Gonzaga is a comune in the Province of Mantua in the Italian region Lombardy, located about 140 kilometres southeast of Milan and abou…Gonzaga is a comune in the Province of Mantua in the Italian region Lombardy, located about 140 kilometres southeast of Milan and about 25 kilometres south of Mantua. Located in a region known as the "Lower Mantuan" is notable for being the ancestral home of the House of Gonzaga, rulers of the Duchy of Mantua between 1328 and 1707.