Methuen is a 23-square-mile city in Essex County, Massachusetts, United States. The population was 53,059 at the 2020 census. Methuen lies …Methuen is a 23-square-mile city in Essex County, Massachusetts, United States. The population was 53,059 at the 2020 census. Methuen lies along the northwestern edge of Essex County, just east of Middlesex County and just south of Rockingham County, New Hampshire. The city is bordered by Haverhill to the northeast, North Andover to the southeast, Lawrence and Andover to the south, Dracut to the west, Pelham, New Hampshire to the northwest, and Salem, New Hampshire to the north. Methuen is located 17 miles southwest from Newburyport, 30 miles north-northwest of Boston and 25 miles south-southeast of Manchester, New Hampshire.