The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, who are in serious danger of missin

The first-place Buffalo Bills are on a six-game winning streak and getting healthier. The last-place San Francisco 49ers have dropped two straight games and are beleaguered by injuries. Buffalo has Super Bowl aspirations and San Francisco played in the ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with just the front four. Buffalo is Top 10 in EPA allowed per pay and very stingy against the run, sitting seventh in run-stop win rate at ESPN and No. 9 in opponent success rate per handoff.

Buffalo is coming out of their bye week ready and willing to tackle the playoff push, with their eyes set on a higher target. The AFC East hasn't been clinched yet, but with six games to play, Buffalo already has a potential hat and t-shirt game on the docket for Sunday Night Football when they host the San Francisco 49ers.

Here’s how you can watch, stream and listen to the game. Bills vs. 49ers will air on NBC. Mike Tirico will be on play-by-play with Cris Collinsworth doing color commentary and Melissa Stark serving as the sideline reporter. Buffalo Kickoff Live will air at 11 a.m. on WNLO and 11:30 a.m. on WIVB.