The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

The San Francisco 49ers are facing an uphill battle in their quest to earn a playoff spot after suffering their second ...

San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

The Buffalo Bills' upcoming opponent, the San Francisco 49ers, provided a big injury update for their starting quarterback ...

But even if the 49ers had the trio of stars, the game’s result likely would have stayed the same (although the score likely ...

Buffalo Bills look to extend its six-game win streak as Josh Allen faces an unfamiliar foe in the San Francisco 49ers at ...

If defense wins championships, NFL quarterbacks win headlines—and a whole lot of blame when things go south. Week 12 gave us ...

Watch a Thanksgiving triple-header live on Sky Sports NFL from 5pm Thursday as the Detroit Lions face the Chicago Bears at ...

San Francisco quarterback Brock Purdy took part in some light throwing on Monday after missing his first career game because ...

32-year-old veteran backup Brandon Allen will start in his place ... It wasn’t always pretty, but the 49ers won’t care. San Francisco beat the Buccaneers with a last-second field goal in ...

Brandon Allen's first start with the 49ers didn't go so well. He made some nice throws, but he fumbled twice, threw an ...

San Francisco head coach Kyle Shanahan discussed what it will take for the 49ers to ignite receiver Deebo Samuel’s production ...