Our top pick for the 49ers vs. Bills Week 13 NFL matchup is to bet on the 49ers +6.5 (+100). This betting advice is ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

In the San Francisco 49ers Week 14 contest against the Chicago Bears, the team will wear their customized cleats on the field ...

After a frustrating bout with an injury, one of the San Francisco 49ers veteran players is hinting at retirement.

The San Francisco 49ers fell to an incomprehensible 5-6 with their Week 12 loss to the Green Bay Packers, and while the 49ers ...

Packers QB Jordan Love didn't throw an interception against the 49ers, snapping his NFL-long streak of eight straight games ...

Buffalo Bills look to extend its six-game win streak as Josh Allen faces an unfamiliar foe in the San Francisco 49ers at ...

The 49ers have a 17% chance of making the playoffs and have one of the toughest remaining schedules -- all while injuries ...

For as up and down as the San Francisco 49ers have been as a franchise ever since Steve Young retired, we are firmly in the ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...