Protease-activated receptor-2 (PAR2) is a class-A G protein-coupled receptor (GPCR) activated by serine proteases and is expressed by multiple tissues, including the skin. PAR2 is involved in the skin ...

Describes how you own a property. There are different types of tenure - freehold, leasehold, and commonhold.Read more about tenure in our glossary page. Spacious open plan lounge/diner, perfect for ...

Glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide and dual GLP-1 and glucose-dependent insulinotropic polypeptide receptor agonists such as tirzepatide could curb both the health ...

However, to date, no clinical trial has specifically evaluated the efficacy of GLP-1 receptor agonists on morbidity and mortality in people with heart failure. Semaglutide was recently shown to ...

Transient Receptor Potential Mucolipin 1 (TRPML1) is a lysosomal cation channel whose loss-of-function mutations directly cause the lysosomal storage disorder mucolipidosis type IV (MLIV). TRPML1 can ...

Pirnik et al. conducted a study wherein they demonstrated that the subcutaneous treatment of a ghrelin receptor agonist, specifically Dpr-(N-octanyl)-3-ghrelin, aided the stimulation of food intake ...

Mean ± SEM (n=2 ON-S RGCs, 2 ON-T RGCs) (C) Excitatory currents measured in response to light step increment in control conditions (cyan) and in the presence of GABA receptor antagonists (10 µM ...

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