This may be the first Thanksgiving for millions of Americans who are on GLP-1 agonists like Ozempic, Zepbound or Wegovy.

For most, Thanksgiving is all about the big meal. The turkey, which may be roasted, smoked, brined or deep fried, side dishes, followed by pies (yes, multiple — pecan? pumpkin? apple?) typically amount to a buffet of choices.

Holidays bring time with family, cultural celebrations and rest, but Thanksgiving, often centralized around food, may also ignite anxiety for some people.